Socioeconomic factors and SGLT2 inhibitor initiation in patients with heart failure—a claims data analysis - Summary - MDSpire

Socioeconomic factors and SGLT2 inhibitor initiation in patients with heart failure—a claims data analysis

  • By

  • Lisa–Marie Müller

  • Jonas Krampe

  • Julius L. Katzmann

  • Ulrich Laufs

  • Alexander Kogel

  • July 7, 2026

  • 0 min

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Objective:

To explore the role of socioeconomic factors in the initiation of SGLT2 inhibitor therapy among patients with chronic heart failure, addressing health disparities in cardiovascular care.

Approach:
  • Data Source: Utilized the German Analysis Database for Evaluation and Health Services Research (DADB) and the INKAR database for demographic and socioeconomic indicators.
  • Study Population: Included individuals with full insurance coverage diagnosed with left ventricular failure or unspecified heart failure in 2023, excluding those with contraindications for SGLT2i therapy.
  • Medication and Outcome: Main outcome was the initiation of SGLT2i therapy (dapagliflozin and empagliflozin) in 2023.
  • Covariate Assessment: Assessed various covariates including age, gender, nationality, socioeconomic status, and health program enrollment.
  • Statistical Methods: Conducted multilevel logistic regression analysis to identify factors associated with SGLT2i initiation.
Key Findings:
  • Socioeconomic factors significantly influence the initiation of SGLT2i therapy in heart failure patients.
  • Disparities in prescription rates may exist based on individual and area-level socioeconomic status.
Interpretation:

The study highlights the need to understand how socioeconomic factors affect access to SGLT2i therapy in heart failure management.

Limitations:
  • The study is limited to claims data, which may not capture all relevant clinical information.
  • Exclusion of patients with contraindications may limit generalizability.
Conclusion:

Understanding the impact of socioeconomic status on SGLT2i initiation can inform strategies to improve access and adherence in heart failure care.

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