Respiratory Syncytial Virus and Human Metapneumovirus Respiratory Hospitalizations and Outcomes in Colorado Adults ≥50 Years of Age: 2016–2023 - Summary - MDSpire
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Respiratory Syncytial Virus and Human Metapneumovirus Respiratory Hospitalizations and Outcomes in Colorado Adults ≥50 Years of Age: 2016–2023
To understand risk factors for hospitalization and outcomes in adults ≥50 years infected with HMPV and compare these with RSV.
Key Findings:
COPD was the highest risk factor for ICU admission in both RSV (aOR 2.24) and HMPV (aOR 2.99).
Neuromuscular disease without dementia also increased ICU admission risk for both viruses.
Age increased mortality odds for RSV but not for HMPV.
Neurological disorders with dementia were the highest comorbidity risk for RSV mortality (aOR 4.16), while COPD was highest for HMPV mortality (aOR 12.44).
Interpretation:
HMPV infection presents a distinct disease burden in older adults, with specific high-risk comorbidities differing from those associated with RSV.
Limitations:
Study relies on ICD-10 codes, which may not capture all cases of HMPV.
Data does not include laboratory testing results, potentially underestimating HMPV incidence.
Conclusion:
HMPV warrants further study due to its unique risk factors and outcomes compared to RSV in older adults.
