Peripheral blood monocytes could be associated with brain metastasis and affect patient prognosis in breast cancer: a retrospective study - Summary - MDSpire
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Peripheral blood monocytes could be associated with brain metastasis and affect patient prognosis in breast cancer: a retrospective study
To test the hypothesis that changes in peripheral blood monocyte-related ratios, particularly the lymphocyte-to-monocyte ratio (LMR), at the time of brain metastases (BM) diagnosis are associated with survival outcomes in breast cancer patients.
High LMR group had a median survival of 20.0 months (95% CI 15.2–28.5) compared to 5.13 months (95% CI 3.9–7.5) in the low group (log-rank p < 0.001).
High platelet-to-monocyte ratio (PMR) group had a median survival of 14.17 months (95% CI 7.0–18.7) versus 5.73 months (95% CI 3.6–9.9) in the low group (log-rank p = 0.028).
Poorer survival was associated with triple-negative breast cancer subtype, low LMR, and higher number of BMs.
Interpretation:
Changes in AMC and monocyte-related ratios at BM diagnosis are indicative of survival outcomes in breast cancer patients, suggesting their potential as important prognostic markers.
Limitations:
Retrospective design may introduce bias.
Single-center study limits generalizability.
Further validation in larger prospective studies is needed.
Conclusion:
Monocyte dynamics at BM diagnosis may serve as exploratory prognostic markers in breast cancer, warranting further investigation.
