3% diquafosol sodium combined with 0.1% fluorometholone for postoperative dry eye in pterygium patients with preoperative tear deficiency: a pilot retrospective study - Summary - MDSpire
Advertisement
3% diquafosol sodium combined with 0.1% fluorometholone for postoperative dry eye in pterygium patients with preoperative tear deficiency: a pilot retrospective study
To evaluate the clinical efficacy and safety of 3% diquafosol sodium combined with 0.1% fluorometholone for postoperative dry eye in pterygium patients with preoperative tear deficiency.
Approach:
Study Design: Single-center retrospective study involving 82 pterygium patients with preoperative tear deficiency.
Patient Groups: Patients were divided into an observation group (diquafosol + fluorometholone, n = 42) and a control group (sodium hyaluronate + fluorometholone, n = 40).
Outcome Measures: Tear break-up time (BUT), corneal fluorescein staining (CFS) score, Ocular Surface Disease Index (OSDI), Schirmer I test (SIt), and intraocular pressure (IOP) were assessed preoperatively and at 2 and 4 weeks postoperatively.
Key Findings:
At 4 weeks postoperatively, the observation group showed significantly longer BUT, lower CFS and OSDI scores, and higher SIt values compared to the control group (all p < 0.05).
No significant intergroup differences in IOP were observed at any time point.
Transient ocular stinging occurred in 2 patients (4.88%) in the observation group, with no severe complications in either group.
Interpretation:
The combination of 3% diquafosol sodium and 0.1% fluorometholone showed preliminary evidence of improving tear film stability, repairing ocular surface damage, and alleviating dry eye symptoms in pterygium patients with preoperative tear deficiency, without significantly affecting IOP.
Limitations:
This was a pilot study with a small sample size.
The study was retrospective and lacked randomization.
Conclusion:
The findings support further investigation in larger, longer-term randomized controlled trials.
