THR-123, a novel BMP-7 mimetic that activates Akt phosphorylation and inhibits cardiomyocyte apoptosis and inflammation, protects the heart from myocardial injury in a Rat model - Summary - MDSpire

THR-123, a novel BMP-7 mimetic that activates Akt phosphorylation and inhibits cardiomyocyte apoptosis and inflammation, protects the heart from myocardial injury in a Rat model

  • By

  • Dattatreyamurty Bosukonda

  • Romesh R. Subramanian

  • Peter C. Keck

  • Philippe Bey

  • Frederic R. Carlson

  • William D. Carlson

  • June 25, 2026

  • 0 min

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Objective:

To evaluate the effects of THR-123, a BMP-7 mimetic, on myocardial damage in a rat model of ischemia-reperfusion injury.

Approach:
  • Animal Model: Utilized a rat model of ischemia-reperfusion injury induced by LAD coronary occlusion to assess the protective effects of THR-123.
  • Mechanistic Studies: Examined the mechanism of action of THR-123 in cardiomyocyte models, focusing on Akt phosphorylation, inflammation, and apoptosis.
Key Findings:
  • THR-123 reduced myocardial infarct size by 84%.
  • THR-123 decreased pericardial inflammation.
  • THR-123 activated Akt phosphorylation in cardiomyocytes.
  • THR-123 inhibited inflammation and apoptosis in cardiomyocytes.
Interpretation:

Limitations:
  • Study conducted in a rat model, which may not fully replicate human responses.
  • Further research needed to evaluate long-term effects and safety in humans.
Conclusion:

Original Source(s)

THR-123, a novel BMP-7 mimetic that activates Akt phosphorylation and inhibits cardiomyocyte apoptosis and inflammation, protects the heart from myocardial injury in a Rat model

  • by Dattatreyamurty Bosukonda, Romesh R. Subramanian, Peter C. Keck, Philippe Bey, Frederic R. Carlson, William D. Carlson

  • June 25, 2026

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