Association of 25(OH)D status with calcium metabolism, inflammation, and thyroid autoimmunity in patients with type 2 diabetes mellitus - Summary - MDSpire

Association of 25(OH)D status with calcium metabolism, inflammation, and thyroid autoimmunity in patients with type 2 diabetes mellitus

  • By

  • Nannan Lv

  • Jianjian Xiang

  • Jinsong Kuang

  • Fei Liu

  • Lan Cheng

  • Shanyu Yin

  • June 4, 2026

  • 0 min

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Objective:

To investigate the clinical associations of serum 25(OH)D levels with calcium metabolism, inflammation, thyroid function, and autoimmunity in patients with T2DM, specifically focusing on how these factors interact.

Key Findings:
  • 83.7% of patients exhibited 25(OH)D deficiency (<20 ng/mL).
  • Higher 25(OH)D levels correlated with lower PTH (P = 0.010) and higher calcium (P<0.001).
  • hsCRP levels peaked in the moderate deficiency group (2.66 mg/L, P<0.001).
  • T3 and fT3 levels were lowest in severe deficiency (P<0.05).
  • TGAb positivity was associated with higher 25(OH)D levels (P = 0.008), while TPOAb positivity was associated with lower levels (P<0.001).
Interpretation:

25(OH)D deficiency is prevalent in T2DM and is associated with altered calcium-PTH homeostasis, elevated inflammation, and suppressed T3 levels.

Limitations:
  • The cross-sectional design limits causal inference, making it difficult to establish direct relationships.
  • Conducting the study in a single center may affect the generalizability of the findings to broader populations.
  • Exclusion of patients with certain conditions may limit the diversity of the sample and affect the applicability of results.
Conclusion:

The study highlights the complex interactions between vitamin D status and thyroid autoimmunity in T2DM patients, suggesting potential areas for clinical intervention.

Original Source(s)

Association of 25(OH)D status with calcium metabolism, inflammation, and thyroid autoimmunity in patients with type 2 diabetes mellitus

  • by Nannan Lv, Jianjian Xiang, Jinsong Kuang, Fei Liu, Lan Cheng, Shanyu Yin

  • June 4, 2026

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