Effects of donor killer-cell immunoglobulin-like receptor genotypes on clinical outcome after allogeneic hematopoietic stem cell transplantation—a systematic review and meta-analysis - Summary - MDSpire

Effects of donor killer-cell immunoglobulin-like receptor genotypes on clinical outcome after allogeneic hematopoietic stem cell transplantation—a systematic review and meta-analysis

  • By

  • Yarui Huang

  • Qingrong Li

  • Xin Xu

  • Ju Li

  • Yan Zhu

  • Chengxin Luo

  • Jiegang Xu

  • Jiaming Liu

  • Jianmin Zhang

  • Ping Wang

  • Ya Tan

  • Yaqun Ding

  • Shuangnian Xu

  • Run Chen

  • Ling Wei

  • July 14, 2026

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Objective:

To evaluate the impact of donor KIR haplotypes on the survival of patients undergoing allo-HSCT.

Approach:
  • Data Analysis: Pooled hazard ratio (HR) for time-to-event data with subgroup analyses based on sample size, area, donor type, T cell replete or deplete, GVHD prophylaxis, and lymphoid or myeloid.
Key Findings:
  • Meta-analysis included 17 eligible studies showing that donor KIR B/X genotype is associated with significantly superior overall survival (HR = 0.68, 95%CI, 0.56-0.82; P<0.0001), reduced relapse incidence (HR = 0.61, 95%CI, 0.44-0.85; P = 0.003), and improved relapse-free survival (HR = 0.61, 95%CI, 0.46-0.81; P = 0.0008).
Interpretation:

The donor KIR B/X haplotype is associated with favorable survival outcomes in allo-HSCT.

Limitations:
  • Inconsistencies in previous studies regarding donor KIR haplotypes.
  • Potential biases in the selection of studies for meta-analysis.
Conclusion:

The findings support the potential utility of donor KIR haplotypes as a reference biomarker for donor selection in allo-HSCT.

Original Source(s)

Effects of donor killer-cell immunoglobulin-like receptor genotypes on clinical outcome after allogeneic hematopoietic stem cell transplantation—a systematic review and meta-analysis

  • by Yarui Huang, Qingrong Li, Xin Xu, Ju Li, Yan Zhu, Chengxin Luo, Jiegang Xu, Jiaming Liu, Jianmin Zhang, Ping Wang, Ya Tan, Yaqun Ding, Shuangnian Xu, Run Chen, Ling Wei

  • July 14, 2026

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