Neurodevelopmental outcomes in adolescents born very and extremely preterm: a prolonged follow-up from a single-center cohort - Summary - MDSpire

Neurodevelopmental outcomes in adolescents born very and extremely preterm: a prolonged follow-up from a single-center cohort

  • By

  • Emanuela Claudia Turco

  • Laura Caiazza

  • Martina Gnazzo

  • Valentina Baldini

  • Giulia Pisanò

  • Cristel Brugnano

  • Lorenzo Petrolini

  • Tommaso Vitali

  • Benedetta Piccolo

  • Beatrice Campana

  • Susanna Esposito

  • Matteo Tonna

  • Maria Carmela Pera

  • June 22, 2026

  • 0 min

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Objective:

To describe neurodevelopmental outcomes in adolescents born very or extremely preterm and examine the predictive value of early Bayley scores on cognitive and motor functioning in adolescence.

Approach:
    Key Findings:
    • MDI scores at 12 and 18 months correlated significantly with Raven QI equivalent scores in adolescence (ρ = 0.705 and ρ = 0.763, p <.01).
    • Early motor scores showed inconsistent predictive associations; only the 18-month PDI reached significance (ρ = 0.583, p =.022).
    • 50% of extremely preterm and 33.3% of very preterm adolescents had psychiatric or neurodevelopmental diagnoses.
    • Visuomotor coordination had the strongest negative correlation with gestational age (r = –0.57).
    • The association at 3 months was weaker and non-significant (ρ = 0.410, p =.052).
    Interpretation:

    The 12–18 month developmental assessment window carries prognostic value for cognitive and motor outcomes in preterm survivors.

    Limitations:
    • The study is based on a small sample size of 29 adolescents.
    • Findings may not be generalizable to broader populations due to the single-center design.
    Conclusion:

    The study supports the implementation of structured multidisciplinary surveillance for preterm survivors.

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