Primary diffuse large b-cell lymphoma of the lip: a case report and literature review - Summary - MDSpire

Primary diffuse large b-cell lymphoma of the lip: a case report and literature review

  • By

  • Pingping Liu

  • Changjiang Xu

  • Liming Yu

  • Xiuying Wang

  • Yan Wang

  • Xiaofei Yan

  • June 8, 2026

  • 0 min

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Objective:

To report a case of primary diffuse large B-cell lymphoma (DLBCL) of the lip, highlighting its diagnostic challenges and treatment options.

Key Findings:
  • Primary DLBCL of the lip is rare, comprising less than 1% of extranodal DLBCL cases.
  • Initial misdiagnosis is common due to overlapping symptoms with benign conditions, which can delay treatment.
  • Successful treatment with R-CHOP chemotherapy led to complete remission, underscoring the need for timely intervention.
Interpretation:

The case highlights the importance of considering lymphoma in persistent lip lesions and emphasizes the need for a multidisciplinary approach for accurate diagnosis and management.

Limitations:
  • The rarity of the condition limits generalizability of findings and may affect the development of standardized treatment protocols.
  • Potential for misdiagnosis may delay treatment, impacting patient outcomes.
Conclusion:

This case emphasizes the diagnostic challenges of rare malignancies in uncommon sites and the importance of timely intervention, reinforcing the need for awareness among healthcare providers.

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