Objective:

To evaluate the effects of vitamin C on organ dysfunction and patient outcomes after out-of-hospital cardiac arrest (OHCA).

Approach:

Key Findings:

• Organ dysfunction worsened significantly in the 10 g vitamin C group compared to placebo (difference of 2.5 SOFA points).
• Functional outcomes and long-term survival were worse with vitamin C treatment in the high-dose group.
• Higher rates of kidney replacement therapy and ICU-acquired weakness were observed in the 10 g group.
• Biomarker analyses showed higher troponin concentrations in the 10 g group.

Interpretation:

Limitations:

• The study had a limited sample size and used deferred consent, affecting the final analysis population.
• The prognostic performance of admission SOFA scores in this population is less established.

Conclusion:

Further research is needed to evaluate the effects of vitamin C after OHCA.

Sources:

• Intensive Care Medicine
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