Clinical significance and functional characterization of RRN3 in gastric cancer: insights from pan-cancer analysis and experimental validation - Summary - MDSpire
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Clinical significance and functional characterization of RRN3 in gastric cancer: insights from pan-cancer analysis and experimental validation
To systematically evaluate the clinical relevance, molecular characteristics, immune-related features, and biological function of RRN3 across cancers, with a focus on gastric cancer (GC).
Key Findings:
RRN3 was upregulated in multiple tumor types, including GC, and high expression was associated with unfavorable overall survival in several cancers.
In GC, RRN3 expression correlated with RNA methylation regulators, immune checkpoint genes, tumor mutation burden, and immune cell infiltration.
Functional experiments indicated that RRN3 knockdown inhibited GC cell proliferation, migration, and invasion, while re-expression of RRN3 partly reversed these effects.
In vivo xenograft experiments supported the role of RRN3 in promoting tumor growth.
