Association of antiretroviral therapy regimens with serum cortisol abnormalities in people living with HIV/AIDS: a retrospective study - Summary - MDSpire
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Association of antiretroviral therapy regimens with serum cortisol abnormalities in people living with HIV/AIDS: a retrospective study
To explore the associated factors of abnormal serum cortisol levels in PLWH and the correlation between different ART regimens.
Approach:
Study Design: A retrospective cross-sectional study was conducted using clinical data of people living with HIV between May 2017 and March 2025.
Key Findings:
In this study involving 117 PLWH, 56 cases (47.9%) exhibited an abnormal high cortisol level.
Group A (hypocortisolemia) exhibited significantly higher diastolic blood pressure and longer duration of HIV diagnosis compared to Group C (hypercortisolemia).
Mean triglyceride levels were significantly elevated in Group C compared to Group B.
Duration of HIV diagnosis was associated with changes in blood cortisol levels (OR = 0.987, P = 0.042).
Among 73 PLWH on stable ART, cortisol levels differed significantly among ART regimen groups (P < 0.05).
NRTIs + PIs regimen was independently associated with reduced cortisol levels (OR = 5.36, P = 0.034).
Interpretation:
The NRTIs + PIs regimen was associated with a significantly higher likelihood of reduced cortisol compared with the NRTIs + NNRTIs regimen.
Conclusion:
The findings suggest that ART regimens may influence cortisol levels in PLWH, with specific regimens showing a greater association with reduced levels.
by Han Yajuan, Chen Xingxing, Jiang Huirong, Wan Jinshu, Zhang Yinhua, Pan Xiuzhen, Muhammad Tahir Khan, Xu Chao, Lin Sizhe, Pan Chih-Lin, Liu Yanrong, He Piao
