To report a case of a 52-year-old patient with schizophrenia presenting with catatonic stupor and concurrent severe physical illnesses, emphasizing the impact of these comorbidities on treatment and outcomes, and to evaluate the effectiveness of a combination treatment of diazepam and aripiprazole.
Key Findings:
The combination treatment resulted in a reduction of catatonic symptoms, with a BFCRS score reduction rate exceeding 70%.
The treatment was deemed relatively safe and effective for high-risk catatonic patients with contraindications to modified electroconvulsive therapy (MECT), and the patient's recovery process included gradual improvement in various functions.
Interpretation:
The combination of diazepam and aripiprazole may provide a new therapeutic option for managing catatonic stupor in patients with significant comorbidities, potentially due to their synergistic effects on neurotransmitter systems.
Limitations:
The study is based on a single case report, limiting generalizability.
Further research is needed to validate the effectiveness of this treatment combination in larger populations, and long-term follow-up data on the patient's condition post-treatment is lacking.
Conclusion:
The combination of diazepam and aripiprazole may be a viable treatment option for catatonic stupor in patients with concurrent severe physical illnesses.
