To compare the diagnostic performance of the Intensive Care Infection Score (ICIS) with CRP, procalcitonin, and white blood cell count for detecting infection in critically ill patients.
Approach:
Design and population: The cohort included critically ill adults admitted to the interdisciplinary ICU of a non-university secondary-care hospital in Vechta, Germany, from 2021 through 2023. Written informed consent was required from the patient or a legal representative within 24 hours of ICU admission; pregnancy was an exclusion criterion.
Reference standard: Four independent, board-certified anesthesiologists with intensive care subspecialty training and at least five years of relevant experience assessed each study day using clinical, laboratory, and microbiological information. They were blinded to ICIS and to one another’s classifications. If the first three experts did not reach consensus, a fourth expert adjudicated the case. Categories were infection, infection likely, infection unlikely, and no infection; infection included bacterial and viral infections without further differentiation.
Interpretation:
The provided context describes the study objective and methods but does not report diagnostic-performance results.
Limitations:
The supplied article context ends during the methods and does not provide study results or reported limitations.
