To explore the changing trends of L1 cortical bone parameters with age, sex, and volumetric bone mineral density (vBMD), and their predictive value in osteoporosis.
Approach:
Key Findings:
Significant differences in L1 cortical bone parameters with age and vBMD, showing a decreasing trend.
In males, AUC values for detecting osteoporosis were 0.77 (thickness), 0.83 (area), and 0.84 (volume).
Average thickness showed the highest sensitivity (82.89%), while average area had the highest specificity (90.00%).
Interpretation:
L1 cortical bone parameters measured by CT are predictive of osteoporosis risk, with significant correlations to age and vBMD, underscoring their importance in clinical practice.
Limitations:
Retrospective design may introduce selection bias.
Sample size may limit generalizability of findings.
Potential confounding factors not controlled for in the study.
Conclusion:
L1 cortical bone parameters can aid in osteoporosis detection, highlighting the importance of cortical bone assessment in clinical practice.
Acidic gum beat sugar-free at cranking out nitric oxide from beetroot juice — exactly backward from what test-tube studies predicted. Also this week: a sleep gene that ignores amyloid, and jackfruit sap moonlighting as a bone-building drug delivery system.
Teriparatide followed by zoledronic acid increased bone mineral density but did not reduce fracture risk compared with standard care in adults with osteogenesis imperfecta.
