First application of whole blood exchange–lymphoplasmapheresis combined transfusion for restoring immune homeostasis of ceftriaxone-induced hemolytic crisis: a case report - Summary - MDSpire
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First application of whole blood exchange–lymphoplasmapheresis combined transfusion for restoring immune homeostasis of ceftriaxone-induced hemolytic crisis: a case report
To report a case of novel plasma exchange treatment for ceftriaxone-induced hemolytic crisis.
Approach:
Case Presentation: A 57-year-old woman developed a ceftriaxone-induced hemolytic crisis characterized by dark brown urine, shock, and a sharp decline in hemoglobin after receiving ceftriaxone. Immediate treatment included discontinuation of ceftriaxone, glucocorticoids, and whol…
Key Findings:
The patient's hemolysis, liver function, and IgM titer significantly improved after WLCT.
The direct Coombs test became negative post-treatment.
The patient was discharged after 10 days and remained stable during a 3-month follow-up.
Interpretation:
WLCT may represent a promising therapeutic option for rapid restoration of intravascular immune homeostasis in ceftriaxone-induced hemolytic crisis.
Limitations:
The efficacy and safety of WLCT need validation in future studies.
Conclusion:
This case marks the first successful application of WLCT for ceftriaxone-induced acute hemolytic crisis.
