Gender differences in autism prevalence: origins of bias and its current scientific relevance - Summary - MDSpire

Gender differences in autism prevalence: origins of bias and its current scientific relevance

  • By

  • Patricia Peña-Casquero

  • Dominika Zofia Wojcik

  • Ricardo Canal-Bedia

  • July 10, 2026

  • 0 min

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Objective:

To review the historical bias in the diagnosis of Autism Spectrum Disorder (ASD) towards a male-centered model and its implications for women and gender-diverse individuals.

Approach:
  • Historical Analysis: The article examines the origins of the male-centered diagnostic model of ASD and its impact on equity in diagnosis and treatment.
  • Contemporary Review: It discusses contemporary manifestations of this bias and the implications for clinical, social, and mental health equity.
Key Findings:
  • ASD has historically been diagnosed four times more frequently in males than females, according to various studies.
  • Recent studies suggest that the sex ratio of ASD diagnoses may converge to nearly 1:1 by early adulthood, as indicated by a nationwide longitudinal study in Sweden.
  • Women often experience delayed diagnosis due to differences in symptom presentation and social camouflaging strategies, which have been documented in multiple studies.
  • The male-centered model has led to misdiagnosis and a lack of appropriate support for women and gender-diverse individuals, as evidenced by historical research.
Interpretation:

The article discusses gender bias in autism diagnosis as a structural constraint rooted in the historical and epistemological construction of autism, affecting diagnostic tools and research priorities.

Limitations:
  • There is no consensus on the definition of 'late diagnosis' in autism.
  • The historical focus on male samples in research has contributed to ongoing diagnostic inequities.
Conclusion:

The paper advocates for a reevaluation of diagnostic practices to address gender disparities in autism diagnosis and improve equity in support and interventions.

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