Objective:

To illustrate the imaging and pathology correlation of granular cell tumors of the breast (GCTB) that mimic invasive breast carcinoma, emphasizing the critical role of preoperative tissue diagnosis to prevent overtreatment.

Approach:

Key Findings:

• GCTB can present with imaging features that mimic invasive breast carcinoma, leading to unnecessary extensive surgeries.
• Preoperative core needle biopsy (CNB) is recommended to differentiate GCTB from malignant conditions, which can prevent unnecessary surgical interventions.
• Histological examination in Case 2 provided direct morphological evidence supporting the Schwann-cell origin of GCTB.

Interpretation:

The cases highlight the diagnostic challenges posed by GCTB in the axillary tail and underscore the necessity for accurate preoperative diagnosis to avoid overtreatment and mismanagement.

Limitations:

• The study is based on only two cases, limiting the generalizability of the findings.
• The reliance on imaging features may not be sufficient for definitive diagnosis without histological confirmation, and potential biases in case selection may exist.

Conclusion:

Both patients remained disease-free at follow-ups of 12 and 36 months, reinforcing the need for careful diagnostic evaluation and histological confirmation of suspicious axillary masses.

Attribution Notice

This content is an AI-generated, fully rewritten summary based on a published scholarly article. It does not reproduce the original text and is not a substitute for the original publication. Readers are encouraged to consult the source for full context, data, and methodology.