Objective:

To elucidate the role of lactylation in tumor progression and its implications for cancer therapy.

Approach:

Key Findings:

• Lactylation is a critical epigenetic mechanism linking metabolic changes to gene regulation in cancer.
• It enhances tumor cell malignancy and promotes immune suppression within the tumor microenvironment.
• Lactate accumulation from the Warburg effect provides a substrate for lactylation, influencing both tumor and immune cell behavior.

Interpretation:

Understanding the lactylation axis establishes a novel metabolic-epigenetic-immune paradigm in cancer biology.

Limitations:

• Current evidence is largely correlative; causal strategies are needed to confirm direct effects of lactylation.
• Technical limitations exist in lactylation detection methods, including specificity and sensitivity issues.

Conclusion:

The lactylation axis represents a potential target for precision cancer therapy by integrating metabolic, epigenetic, and immune perspectives.

Attribution Notice

This content is an AI-generated, fully rewritten summary based on a published scholarly article. It does not reproduce the original text and is not a substitute for the original publication. Readers are encouraged to consult the source for full context, data, and methodology.