Diabetic retinopathy and the risk of all-cause dementia, Alzheimer’s disease, and vascular dementia: a systematic review and meta-analysis - Summary - MDSpire
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Diabetic retinopathy and the risk of all-cause dementia, Alzheimer’s disease, and vascular dementia: a systematic review and meta-analysis
To quantitatively assess the relationship between diabetic retinopathy (DR) and the risk of all-cause dementia (ACD), Alzheimer’s disease (AD), and vascular dementia (VD).
Approach:
Data Sources: Literature search conducted in PubMed, Embase, and Web of Science up to September 2023.
Key Findings:
Diabetic retinopathy is significantly associated with higher risks of all-cause dementia (HR = 1.24, 95% CI [1.14, 1.36], p < 0.00001).
Diabetic retinopathy is associated with an increased risk of vascular dementia (HR = 1.20, 95% CI [1.05, 1.37], p = 0.009).
Diabetic retinopathy is linked to a higher risk of Alzheimer's disease (HR = 1.23, 95% CI [1.11, 1.37], p < 0.00001).
Interpretation:
Limitations:
The study acknowledges inherent limitations and calls for further high-quality prospective cohort studies.
Conclusion:
Current evidence indicates that DR is associated with an elevated risk of ACD, AD, and VD.
