In-vitro flow assessment study of intra-saccular endovascular devices for brain aneurysm treatment: SEAL™ vs. WEB™ - Summary - MDSpire

In-vitro flow assessment study of intra-saccular endovascular devices for brain aneurysm treatment: SEAL™ vs. WEB™

  • By

  • Hamid Mansouri

  • Nedim Gulkaya

  • Matthew J. Gounis

  • Mohammad AlMajali

  • Amit Chaudhari

  • Darwin G. Ramirez Abreu

  • Syed F. Zaidi

  • Yazan K. Ashouri

  • Naoki Kaneko

  • Brian T. Jankowitz

  • David J. Altschul

  • Boris Pabon

  • Pervinder Bhogal

  • Thomas J. Wolfe

  • Edgard L. Pereira

  • Aamir Badruddin

  • Laila Ibrahim

  • Omid Amili

  • Osama O. Zaidat

  • June 19, 2026

  • 0 min

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Objective:

To use the particle image velocimetry (PIV) method for flow characterization with intra-saccular devices and compare flow dynamics between SEAL and WEB devices.

Approach:
    Key Findings:
    • Mean residence time (RT) was 0.387 ± 0.128 s for SEAL-BASE, 0.33 ± 0.092 s for SEAL-ARC, and 0.171 ± 0.034 s for WEB-SL, with all p < 0.05 vs. control.
    • Vorticity strength (VS) decreased from 66.48 ± 8.58 1/s (control) to 14.06 ± 2.80 for SEAL-BASE, 13.94 ± 2.53 for SEAL-ARC, and 27.60 ± 4.16 for WEB-SL, with p = 0.007 and 0.006 for SEAL vs. WEB-SL.
    • Velocity magnitude dropped from 109.4 ± 15.5 mm/s (control) to 12.42 ± 3.8 mm/s for SEAL-BASE, 14.2 ± 3.5 mm/s for SEAL-ARC, and 25.34 ± 3.16 mm/s for WEB-SL, with p = 0.006 and 0.007 for SEAL vs. WEB-SL.
    Interpretation:

    Both SEAL configurations achieved greater flow reduction compared to WEB-SL in the same aneurysm model, indicating potential for optimization of neurointerventional devices.

    Limitations:
    • In vitro conditions may not fully replicate in vivo hemodynamics.
    • The study was limited to a specific aneurysm model and device configurations.
    Conclusion:

    Results demonstrate the utility of the PIV method for evaluating flow dynamics in intra-saccular devices, highlighting differences in performance between SEAL and WEB devices.

Original Source(s)

In-vitro flow assessment study of intra-saccular endovascular devices for brain aneurysm treatment: SEAL™ vs. WEB™

  • by Hamid Mansouri, Nedim Gulkaya, Matthew J. Gounis, Mohammad AlMajali, Amit Chaudhari, Darwin G. Ramirez Abreu, Syed F. Zaidi, Yazan K. Ashouri, Naoki Kaneko, Brian T. Jankowitz, David J. Altschul, Boris Pabon, Pervinder Bhogal, Thomas J. Wolfe, Edgard L. Pereira, Aamir Badruddin, Laila Ibrahim, Omid Amili, Osama O. Zaidat

  • June 19, 2026

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