Case Report: Synovial sarcoma with diffuse myxoid stroma and complete absence of epithelial differentiation in the extremity - Summary - MDSpire

Case Report: Synovial sarcoma with diffuse myxoid stroma and complete absence of epithelial differentiation in the extremity

  • By

  • Tomohiro Miyazaki

  • Naoki Oike

  • Takashi Ariizumi

  • Yudai Murayama

  • Akira Ogose

  • Hideaki Sugino

  • Mai Nakamura

  • Shuhei Kondo

  • Yusuke Tani

  • Hajime Umezu

  • Hiroyuki Kawashima

  • May 29, 2026

  • 0 min

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Objective:

To report a rare presentation of synovial sarcoma with diffuse myxoid stroma and absence of epithelial marker expression, highlighting diagnostic challenges.

Key Findings:
  • The tumor exhibited a diffuse myxoid stroma and lacked epithelial marker expression.
  • Diagnosis of synovial sarcoma was confirmed through molecular identification of the SS18–SSX1 fusion transcript, supported by fluorescence in situ hybridization and reverse transcription polymerase chain reaction.
  • The case illustrates the potential for synovial sarcoma to mimic other myxoid sarcomas, complicating diagnosis.
Interpretation:

Remove this section.

Limitations:
  • The case is based on a single patient, limiting generalizability.
  • No druggable genomic alterations were identified in the comprehensive genomic profiling.
Conclusion:

Revise to state: 'This case highlights the diagnostic complexity of synovial sarcoma with myxoid features.'

Original Source(s)

Case Report: Synovial sarcoma with diffuse myxoid stroma and complete absence of epithelial differentiation in the extremity

  • by Tomohiro Miyazaki, Naoki Oike, Takashi Ariizumi, Yudai Murayama, Akira Ogose, Hideaki Sugino, Mai Nakamura, Shuhei Kondo, Yusuke Tani, Hajime Umezu, Hiroyuki Kawashima

  • May 29, 2026

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