Tamsulosin Deprescribing for Lower Urinary Tract Symptoms in Older Men: A Randomized Clinical Trial - Summary - MDSpire

Tamsulosin Deprescribing for Lower Urinary Tract Symptoms in Older Men: A Randomized Clinical Trial

  • By

  • Scott R. Bauer

  • Stacey A. Kenfield

  • Akinyemi Oni-Orisan

  • Michael G. Shlipak

  • Kaiwei Lu

  • Natalie Rios

  • Robert Pearce

  • Joseph Harmon

  • Charles E. McCulloch

  • Liusheng Huang

  • Michael A. Steinman

  • Benjamin N. Breyer

  • July 6, 2026

  • 0 min

Share

Objective:

To determine if placebo-controlled N-of-1 deprescribing trials can identify older men receiving chronic tamsulosin therapy for LUTS who are likely to benefit from stopping this treatment.

Approach:
  • Methodology: Participants underwent two 5-week cycles of treatment with tamsulosin and placebo, separated by a 1-week washout period to ensure the elimination of the drug before the next treatment phase.
Key Findings:
  • The study aimed to evaluate the efficacy of tamsulosin compared to placebo in older men with LUTS.
  • The N-of-1 trial design allows for personalized assessment of treatment benefits and harms.
Interpretation:

The study's design and methodology aim to provide insights into individualized treatment assessments for LUTS in older men.

Limitations:
  • The study may not generalize to all older men with LUTS due to specific inclusion criteria, such as age and health status.
  • The minimal clinically important difference for the modified AUASI has not been established.
Conclusion:

The study seeks to clarify the role of tamsulosin in managing LUTS among older men.

Original Source(s)

Tamsulosin Deprescribing for Lower Urinary Tract Symptoms in Older Men: A Randomized Clinical Trial

  • by Scott R. Bauer, Stacey A. Kenfield, Akinyemi Oni-Orisan, Michael G. Shlipak, Kaiwei Lu, Natalie Rios, Robert Pearce, Joseph Harmon, Charles E. McCulloch, Liusheng Huang, Michael A. Steinman, Benjamin N. Breyer

  • July 6, 2026

Related Content

Correction: Hopefulness among individuals living with schizophrenia and their caregivers in Tanzania: an actor-partner interdependence model

Temporal association of constipation and diarrhoea with a subsequent diagnosis of colorectal cancer: a propensity score–matched case–control study using real-world primary care data

Beyond the physician shortage: infrastructure as a rate-limiting step in breast cancer care