Objective:

To summarize clinical data regarding fever management in sepsis and provide evidence-based guidance for clinicians.

Key Findings:

• Fever stimulates immune responses and inhibits microbial growth through various mechanisms.
• Temperature extremes in sepsis (hypothermia and hyperthermia) are associated with adverse outcomes.
• Antipyretic therapy may negatively impact septic patients, necessitating individualized approaches.

Interpretation:

Fever may play a protective role in sepsis, and its suppression could be detrimental to patient outcomes, warranting cautious use of antipyretics.

Limitations:

• Observational studies may not establish causation.
• Variability in individual patient responses to fever and temperature management.
• More randomized controlled trials are needed to strengthen the evidence base.

Conclusion:

Fever should not be indiscriminately treated in septic patients; individualized management is crucial.