Perioperative corticosteroids and pancreatic surgery outcomes: a systematic review and meta-analysis combining human expertise and AI support (ChatGPT) - Summary - MDSpire
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Perioperative corticosteroids and pancreatic surgery outcomes: a systematic review and meta-analysis combining human expertise and AI support (ChatGPT)
To synthesize current evidence regarding the role of perioperative corticosteroids (CCS) in pancreatic resections, focusing on their impact on postoperative outcomes.
Approach:
Eligibility criteria: Included studies on adult patients undergoing pancreatic resection with perioperative CCS administration.
Search strategy: Systematic search conducted in Medline, Web of Science, and Cochrane Library following PRISMA guidelines.
Study selection: Included observational and randomized controlled studies; excluded animal studies, case reports, and reviews.
Data extraction: Data on study characteristics and postoperative outcomes were extracted and assessed for eligibility.
Statistical analysis: Quality assessment and statistical analysis were performed using Review Manager 5.4, with significance set at P < 0.05.
Key Findings:
Corticosteroids may reduce postoperative complications in pancreatic surgery.
Current clinical practice regarding CCS use is heterogeneous.
Previous reviews on CCS in pancreatic surgery had methodological limitations.
Interpretation:
Limitations:
Inconsistencies in previous studies.
Variability in clinical practice and lack of standardized protocols.
