Amino acid-based formula with synbiotics for cow's milk protein allergy: a real-world study of symptom evolution and quality-of-life outcomes - Summary - MDSpire
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Amino acid-based formula with synbiotics for cow's milk protein allergy: a real-world study of symptom evolution and quality-of-life outcomes
To describe changes in symptom scores and caregiver-reported outcomes over 28 days following initiation of an amino acid-based formula containing synbiotics in infants with suspected or confirmed CMPA in routine practice.
Approach:
Study Design: Prospective, multicenter, observational, single-arm real-world cohort study conducted in 10 centers in Argentina between May 2022 and May 2023.
Key Findings:
Mean CoMiSS decreased from 10.1 (SD 4.6) at baseline to 3.5 (SD 2.2) on Day 28.
Median IGSQ-13 and PO-SCORAD scores decreased over 28 days.
FAQL-PB scores also decreased, indicating improved caregiver-reported quality of life.
Caregiver-reported stool frequency and regurgitation improved over time.
Interpretation:
Symptom scores and caregiver-reported outcomes improved over 28 days following the initiation of the amino acid-based formula with synbiotics in infants with CMPA.
Limitations:
Observational nature of the study limits causal inference.
Findings may not be generalizable beyond the study population.
Conclusion:
The study observed improvements in symptoms and quality of life measures in infants with CMPA after 28 days of treatment with an amino acid-based formula containing synbiotics.
