Objective:

To elucidate the roles of MHR and LHR in the impact of hypertriglyceridemia on hyperuricemia in diabetes mellitus, with implications for clinical management.

Key Findings:

• Participants with HTG and HUA had significantly elevated MHR and LHR levels (P < 0.001).
• MHR was significantly associated with HTG (OR 1.59, 95% CI) and HUA (OR 1.13, 95% CI).
• LHR showed independent correlations with HTG (OR 2.34, 95% CI) and HUA (OR 1.63, 95% CI).
• MHR exhibited a nonlinear relationship with HTG and HUA, while LHR showed a linear correlation.
• MHR and LHR partially mediated the effect of HTG on HUA, accounting for 20.51% and 37.17% of the mediated proportion, respectively.

Interpretation:

The findings suggest that inflammation and oxidative stress, as indicated by MHR and LHR, play significant roles in the relationship between hypertriglyceridemia and hyperuricemia in diabetes mellitus, impacting management strategies.

Limitations:

• Cross-sectional design limits causal inference.
• Potential confounding factors, such as lifestyle and medication use, may not have been fully accounted for.

Conclusion:

MHR and LHR are important mediators in the relationship between hypertriglyceridemia and hyperuricemia, highlighting the role of inflammation and oxidative stress in diabetes management and suggesting avenues for future research.