Risk factors of atrial fibrillation progression in patients with congenital heart disease - Summary - MDSpire

Risk factors of atrial fibrillation progression in patients with congenital heart disease

  • By

  • Can Zhang

  • Nawin L. Ramdat Misier

  • Lixia Dai

  • Manouk H. C. Linderhof

  • Hoang H. Nguyen

  • Annemien E. van den Bosch

  • Vehpi Yildirim

  • Mathijs S. van Schie

  • Yannick J. H. J. Taverne

  • Natasja M. S. de Groot

  • June 29, 2026

  • 0 min

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Objective:

To investigate long-term atrial fibrillation (AF) progression in adults with congenital heart disease (CHD) and identify independent risk factors.

Approach:
  • Study Design: Retrospective longitudinal study part of the DANARA project, including CHD patients with at least one AF episode.
  • Data Collection: Clinical data extracted from electronic medical records, including demographics, CHD classification, and treatment history.
  • AF Progression Assessment: AF progression defined as a change from paroxysmal to persistent or permanent AF, verified through ECG and monitoring data.
  • Statistical Analysis: Cox proportional hazards models used to assess associations between covariates and AF progression risk.
Key Findings:
  • AF progression occurred in 57 (45.6%) of 125 CHD patients during a mean follow-up of 17 years.
  • Mean age at AF onset was 40 years; progression occurred at a mean age of 50 years.
  • Patients with AF progression were more frequently female and had less severe complex CHD.
Interpretation:

Limitations:
  • Retrospective design may introduce bias.
  • Single-center study limits generalizability.
Conclusion:

Original Source(s)

Risk factors of atrial fibrillation progression in patients with congenital heart disease

  • by Can Zhang, Nawin L. Ramdat Misier, Lixia Dai, Manouk H. C. Linderhof, Hoang H. Nguyen, Annemien E. van den Bosch, Vehpi Yildirim, Mathijs S. van Schie, Yannick J. H. J. Taverne, Natasja M. S. de Groot

  • June 29, 2026

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