Preoperative risk score for malignancy in Bethesda III thyroid nodules: a multicentre retrospective study - Summary - MDSpire

Preoperative risk score for malignancy in Bethesda III thyroid nodules: a multicentre retrospective study

  • By

  • Manuel Carpio-Salmerón

  • Mariano Tébar-Caballero

  • Pau Benito

  • Clemente García-Hidalgo

  • Georgios Kyriakos

  • Antonio Ríos-Vergara

  • Ginés Luengo-Gil

  • Carlos Carazo-Casas

  • Ana Casas-Miras

  • Luis Marín-Martínez

  • Ana Belén Arroyo

  • July 6, 2026

  • 0 min

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Objective:

To characterize surgically resected Bethesda III thyroid nodules and develop a preoperative risk score for malignancy prediction using routinely available variables.

Approach:
  • Participants: Adults with Bethesda III thyroid nodules who underwent thyroidectomy between 2020 and 2025 were included, totaling eighty-five nodules.
Key Findings:
  • Eighty-five nodules were included, with a malignancy rate of 23.5%.
  • Three preoperative variables were independently associated with malignancy: moderate-to-high ultrasound risk, nuclear atypia on fine-needle aspiration, and lymphocytic thyroiditis on fine-needle aspiration.
  • The risk score ranged from 0 to 15 points, with a cut-off of 10 points or higher providing the best overall diagnostic performance. The predicted probability of malignancy ranged from 2.4% to 74.8% across the score spectrum.
Interpretation:

Limitations:
  • Limited sample size may affect the robustness of the findings.
  • Caution is required in interpreting the internal bootstrap validation results.
Conclusion:

Original Source(s)

Preoperative risk score for malignancy in Bethesda III thyroid nodules: a multicentre retrospective study

  • by Manuel Carpio-Salmerón, Mariano Tébar-Caballero, Pau Benito, Clemente García-Hidalgo, Georgios Kyriakos, Antonio Ríos-Vergara, Ginés Luengo-Gil, Carlos Carazo-Casas, Ana Casas-Miras, Luis Marín-Martínez, Ana Belén Arroyo

  • July 6, 2026

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