Long-Term Persistence of Glycemic Dysregulation in Patients With a History of Pheochromocytoma/Paraganglioma - Summary - MDSpire

Long-Term Persistence of Glycemic Dysregulation in Patients With a History of Pheochromocytoma/Paraganglioma

  • By

  • Alessa Fischer

  • Hanna Remde

  • Christina Pamporaki

  • Ulrich Dischinger

  • Nicole Bechmann

  • Mercedes Robledo

  • Katharina Wang

  • Diana Vetter

  • José Oberholzer

  • Grégoire B Morand

  • Simon Andreas Mueller

  • Alexander Huber

  • Ralph Fritsch

  • Sven Gruber

  • Constanze Hantel

  • Kathrin Zitzmann

  • Martin Reincke

  • Christoph J Auernhammer

  • Karel Pacak

  • Ashley B Grossman

  • Felix Beuschlein

  • Svenja Nölting

  • January 2, 2025

  • 0 min

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Objective:

To determine whether markers of elevated cardiometabolic risk persist in patients following the resection of pheochromocytomas and paragangliomas (PPGLs), emphasizing the importance of long-term monitoring.

Key Findings:
  • Patients with a history of PPGL showed a significantly higher prevalence of hyperglycemic disorders compared to asymptomatic pathogenic variant carriers (P = .013), highlighting the need for ongoing monitoring.
  • In patients with a history of PPGL and at least 12 months of follow-up post-surgery, the prevalence of hyperglycemic disorders was significantly higher (P < .001) compared to controls, indicating persistent risk.
  • Mean HbA1c was significantly higher in the PPGL group (5.63%, SD 0.43%) compared to controls (5.45%, SD 0.40%; P = .004), underscoring the need for targeted interventions.
Interpretation:

Glycemic disturbances persist long-term after the resection of PPGL, indicating a need for ongoing cardiometabolic monitoring and tailored follow-up strategies in these patients.

Limitations:
  • Retrospective design may introduce selection bias, potentially affecting the generalizability of the findings.
  • Limited sample size and potential confounding factors not accounted for may influence the results.
Conclusion:

Patients with a history of PPGL require specialized cardiometabolic follow-up due to persistent glycemic dysregulation post-surgery, necessitating the development of specific monitoring protocols.

Original Source(s)

Long-Term Persistence of Glycemic Dysregulation in Patients With a History of Pheochromocytoma/Paraganglioma

  • by Alessa Fischer, Hanna Remde, Christina Pamporaki, Ulrich Dischinger, Nicole Bechmann, Mercedes Robledo, Katharina Wang, Diana Vetter, José Oberholzer, Grégoire B Morand, Simon Andreas Mueller, Alexander Huber, Ralph Fritsch, Sven Gruber, Constanze Hantel, Kathrin Zitzmann, Martin Reincke, Christoph J Auernhammer, Karel Pacak, Ashley B Grossman, Felix Beuschlein, Svenja Nölting

  • January 2, 2025

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