Evidence-based interventions to restore or improve female fertility in women aged 30–42 years: a systematic review by etiology and evidence level - Summary - MDSpire

Evidence-based interventions to restore or improve female fertility in women aged 30–42 years: a systematic review by etiology and evidence level

  • By

  • Maria Jimena Barroso Alverde

  • Sion Yu

  • Daniel Pascal Pontón

  • Denise Niza Benardete Harari

  • José Elias Tesone Lasman

  • June 9, 2026

  • 0 min

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Objective:

To synthesize evidence on interventions that restore or improve fertility in women aged 30–42 years, grouped by etiology.

Key Findings:
  • text
Interpretation:

Established hormonal and ART strategies improve pregnancy outcomes for women aged 30–42 years, but certainty for live birth and safety remains limited.

Limitations:
  • Limited safety reporting in studies.
  • Small sample sizes and heterogeneity affect evidence certainty.
  • Lack of standardized definitions and outcome measures across studies.
Conclusion:

Clinical care should prioritize standard therapies and shared decision-making, acknowledging evidence gaps. Future trials must focus on live birth and standardized outcomes.

Original Source(s)

Evidence-based interventions to restore or improve female fertility in women aged 30–42 years: a systematic review by etiology and evidence level

  • by Maria Jimena Barroso Alverde, Sion Yu, Daniel Pascal Pontón, Denise Niza Benardete Harari, José Elias Tesone Lasman

  • June 9, 2026

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