Oral Microbiome Richness Tied to CRS - Summary - MDSpire
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Oral Microbiome Richness Tied to CRS
A cross-sectional metagenomic study found greater oral microbiome richness among adults with chronic rhinosinusitis, particularly nonallergic chronic rhinosinusitis, while associations with asthma, airway inflammation, and most lung-function measures were inconsistent.
To investigate the association between oral microbiome richness and chronic rhinosinusitis (CRS) and other respiratory outcomes.
Approach:
Study Design: Cross-sectional analysis of adults from the European Community Respiratory Health Survey across three centers.
Participants: Gingival sampling performed on 355 participants, with metagenomic sequencing successful for 335 samples.
Outcomes Measured: Respiratory outcomes included asthma, chronic rhinosinusitis, sensitization status, spirometry, and fractional exhaled nitric oxide.
Data Analysis: Adjusted analyses were conducted to assess associations between oral microbiome richness and respiratory outcomes.
Key Findings:
Increasing oral microbiome richness was associated with chronic rhinosinusitis overall, with the strongest association among participants with nonallergic chronic rhinosinusitis.
No consistent association was observed between alpha diversity and asthma, forced expiratory volume in 1 second, or fractional exhaled nitric oxide.
Functional gene profiling revealed broader differences, with many unique genes present in participants without asthma or chronic rhinosinusitis.
Interpretation:
Increased richness of the oral microbiome is associated with a higher prevalence of nonallergic chronic rhinosinusitis.
Limitations:
Cross-sectional design limits conclusions about causality.
Cohort was enriched for participants with respiratory symptoms, not representative of the general population.
Recent antibiotic-use data were unavailable.
Asthma and chronic rhinosinusitis were based on questionnaire responses, potentially leading to misclassification.
Conclusion:
The study found an association between oral microbiome richness and chronic rhinosinusitis, particularly nonallergic types, while no consistent association with asthma was found.
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