Effects of exercise training on nitric oxide metabolites in heart failure with reduced or preserved ejection fraction: a secondary analysis of the SMARTEX-HF and OptimEx-Clin trials - Summary - MDSpire

Effects of exercise training on nitric oxide metabolites in heart failure with reduced or preserved ejection fraction: a secondary analysis of the SMARTEX-HF and OptimEx-Clin trials

  • By

  • Sophia Marie-Theres Dinges

  • Edzard Schwedhelm

  • Julia Schoenfeld

  • Andreas B Gevaert

  • Ephraim B Winzer

  • Bernhard Haller

  • Flavia Baldassarri

  • Axel Pressler

  • André Duvinage

  • Rainer Böger

  • Axel Linke

  • Volker Adams

  • Burkert Pieske

  • Frank Edelmann

  • Håvard Dalen

  • Torstein Hole

  • Alf Inge Larsen

  • Patrick Feiereisen

  • Trine Karlsen

  • Eva Prescott

  • Øyvind Ellingsen

  • Emeline M Van Craenenbroeck

  • Martin Halle

  • Stephan Mueller

  • March 14, 2025

  • 0 min

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Objective:

To investigate the effects of different exercise modes on nitric oxide (NO) metabolites in patients with heart failure (HF) with reduced (HFrEF) and preserved ejection fraction (HFpEF), addressing the uncertainty surrounding these effects.

Key Findings:
  • Baseline hArg and ADMA levels were significantly higher in HFrEF compared to HFpEF, indicating a potential biomarker for disease severity.
  • NO metabolites correlated with HF severity markers like exercise capacity (VO2peak) and NT-proBNP, but not with endothelial function measures, suggesting a complex relationship.
  • No significant differences in NO metabolite levels were observed between exercise groups (HIIT, MCT, CG) after 3 months or at 12-month follow-up, indicating that exercise mode may not influence NO bioavailability.
Interpretation:

Exercise training did not significantly influence circulating NO metabolites in either HFrEF or HFpEF patients, despite associations with disease severity, suggesting the need for further investigation into other influencing factors.

Limitations:
  • The study did not find significant effects of exercise training on NO metabolites, which may limit the interpretation of exercise's role in endothelial function; potential biases or confounding factors should be considered.
  • The sample size and demographic differences between HFrEF and HFpEF groups may affect generalizability, highlighting the need for larger, more diverse studies.
Conclusion:

Exercise training modes (HIIT and MCT) did not significantly alter NO metabolite levels in patients with HFrEF or HFpEF, indicating that other factors may influence NO bioavailability in heart failure, and future research should explore these factors.

Original Source(s)

Effects of exercise training on nitric oxide metabolites in heart failure with reduced or preserved ejection fraction: a secondary analysis of the SMARTEX-HF and OptimEx-Clin trials

  • by Sophia Marie-Theres Dinges, Edzard Schwedhelm, Julia Schoenfeld, Andreas B Gevaert, Ephraim B Winzer, Bernhard Haller, Flavia Baldassarri, Axel Pressler, André Duvinage, Rainer Böger, Axel Linke, Volker Adams, Burkert Pieske, Frank Edelmann, Håvard Dalen, Torstein Hole, Alf Inge Larsen, Patrick Feiereisen, Trine Karlsen, Eva Prescott, Øyvind Ellingsen, Emeline M Van Craenenbroeck, Martin Halle, Stephan Mueller

  • March 14, 2025

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