Objective:

To evaluate nationwide emotional responses to the arrival of COVID-19 vaccines using social media data.

Key Findings:

• The first COVID-19 vaccine administration was associated with increases in joy and anger, alongside a decline in fear.
• Emotional responses to scientific progress are layered and heterogeneous, with joy reflecting hope and anger arising from frustration and mistrust.
• Communities with higher COVID-19 death tolls showed larger increases in joy and smaller increases in anger.
• Democratic-leaning counties experienced larger increases in joy and decreases in fear compared to Republican-leaning counties.
• Anger is a significant emotional response that can undermine clinician-patient relationships and complicate public health efforts.

Interpretation:

Remove all editorial interpretations and focus solely on findings.

Limitations:

• Social media data may not represent all populations and should be interpreted as directional rather than population-prevalence estimates.
• The study does not evaluate the effectiveness of tailored communication strategies in clinical settings.

Conclusion:

Remove unsupported claims and focus on findings.