To evaluate serum homocysteine and B-vitamin levels in young Saudi patients with premature acute coronary syndrome (ACS).
Approach:
Study Design: A single-center cross-sectional exploratory study involving 80 patients with premature ACS at King Fahd Military Medical Complex, Dhahran, Saudi Arabia.
Data Collection: Clinical, laboratory, electrocardiographic, echocardiographic, angiographic, and SYNTAX score II 2020 data were collected.
Statistical Analysis: Spearman correlation was used to assess associations between homocysteine and B-vitamin levels.
Key Findings:
A weak but statistically significant inverse association was found between homocysteine and folate levels (rho = −0.254, p = 0.040; approximate R2 = 0.065).
No statistically significant correlations were observed between homocysteine and vitamins B12, B1, and B6.
Most patients had low SYNTAX score categories.
Interpretation:
The study provides preliminary data on homocysteine and B-vitamin status among young Saudi patients with premature ACS.
Limitations:
Small sample size of 80 patients.
Absence of a control group.
Risk of model instability in exploratory ordinal regression.
Conclusion:
The findings highlight the need for larger, controlled, multicenter studies to further explore the relationships between homocysteine, B-vitamins, and premature ACS.
by Khalid Alfaraidy, Ayman Mohamed, Alexander Woodman, Rehab Al-Ansari, Yasser A. Al Malki, Fatimah S. Alayidh, Yaser Alnaam, Abdulrahman Al Husil, Mohamed I. Amin, Masniwati Sigem, Yousef M. Hawsawi, Lamiaa H. Al-Jamea
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