To evaluate the time to and rates of achieving quadruple therapy in veterans with newly diagnosed heart failure with reduced ejection fraction (HFrEF).
Key Findings:
Less than 25% of patients achieved quadruple therapy during a median follow-up of 2.9 years.
Median time to quadruple therapy was over 6 months.
21% of patients (n = 11,217) achieved quadruple therapy.
78% had at least one prescription for a beta-blocker, 79% for a renin-angiotensin system inhibitor, 38% for a mineralocorticoid receptor antagonist, and 46% for an SGLT2 inhibitor.
Mortality rate was approximately 31%, with 91% of deaths occurring before quadruple therapy was achieved.
