Surgical management of Glioma Grade 4: technical update from the neuro-oncology section of the Italian Society of Neurosurgery (SINch®): a systematic review - Summary - MDSpire

Surgical management of Glioma Grade 4: technical update from the neuro-oncology section of the Italian Society of Neurosurgery (SINch®): a systematic review

  • By

  • Tamara Ius

  • Giovanni Sabatino

  • Pier Paolo Panciani

  • Marco Maria Fontanella

  • Roberta Rudà

  • Antonella Castellano

  • Giuseppe Maria Vincenzo Barbagallo

  • Francesco Belotti

  • Riccardo Boccaletti

  • Giuseppe Catapano

  • Gabriele Costantino

  • Alessandro Della Puppa

  • Francesco Di Meco

  • Filippo Gagliardi

  • Diego Garbossa

  • Antonino Francesco Germanò

  • Maurizio Iacoangeli

  • Pietro Mortini

  • Alessandro Olivi

  • Federico Pessina

  • Fabrizio Pignotti

  • Giampietro Pinna

  • Antonino Raco

  • Francesco Sala

  • Francesco Signorelli

  • Silvio Sarubbo

  • Miran Skrap

  • Giannantonio Spena

  • Teresa Somma

  • Carmelo Sturiale

  • Filippo Flavio Angileri

  • Vincenzo Esposito

  • March 24, 2023

  • 0 min

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Objective:

To provide an overview of current trends and technical tools in the surgical management of Glioma Grade 4 (GG4), highlighting their significance for patient outcomes.

Key Findings:
  • Gliomas have an annual incidence of approximately six cases per 100,000 people, with a slight male predominance, indicating a need for targeted interventions.
  • The 2021 WHO Classification includes Astrocytomas IDH-mutant Grade 4 and IDH wild-type astrocytomas, defining the Glioblastoma class, which has significant prognostic implications.
  • Extent of resection (EOR) is a significant predictive survival factor for GG4 patients, emphasizing the importance of surgical precision.
  • Surgical treatment remains the standard of care, complemented by radiotherapy and chemotherapy, highlighting the multidisciplinary approach required.
  • Technological advancements have improved surgical safety and increased total resection rates, which is crucial for enhancing patient outcomes.
Interpretation:

Surgical management of GG4 is complex due to the infiltrative nature of the tumors, necessitating advanced techniques to optimize resection while minimizing risks, which is critical for improving survival rates.

Limitations:
  • The review excludes non-English publications and studies focusing on children, which may limit the generalizability of the findings.
  • Single patient case reports and review articles were not included, potentially overlooking valuable insights from these sources.
Conclusion:

Continued advancements in surgical techniques and technologies are essential for improving outcomes in GG4 management, underscoring the need for ongoing research and innovation.

Original Source(s)

Surgical management of Glioma Grade 4: technical update from the neuro-oncology section of the Italian Society of Neurosurgery (SINch®): a systematic review

  • by Tamara Ius, Giovanni Sabatino, Pier Paolo Panciani, Marco Maria Fontanella, Roberta Rudà, Antonella Castellano, Giuseppe Maria Vincenzo Barbagallo, Francesco Belotti, Riccardo Boccaletti, Giuseppe Catapano, Gabriele Costantino, Alessandro Della Puppa, Francesco Di Meco, Filippo Gagliardi, Diego Garbossa, Antonino Francesco Germanò, Maurizio Iacoangeli, Pietro Mortini, Alessandro Olivi, Federico Pessina, Fabrizio Pignotti, Giampietro Pinna, Antonino Raco, Francesco Sala, Francesco Signorelli, Silvio Sarubbo, Miran Skrap, Giannantonio Spena, Teresa Somma, Carmelo Sturiale, Filippo Flavio Angileri, Vincenzo Esposito

  • March 24, 2023

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