To investigate the association between serum DHA, EPA, and MPV with the onset of CAD, the severity of coronary artery stenosis, and the prognosis of major adverse cardiovascular events (MACE), while validating the mediating effect of MPV.
Approach:
Study Design: A total of 183 patients with CAD and 189 controls were included. Various analyses including logistic regression, Spearman correlation, bootstrap mediation, Kaplan–Meier survival, and Cox proportional hazards regression were employed.
Biochemical Measurements: Levels of EPA, DHA, and AA were measured using ultra-performance liquid chromatography-mass spectrometry.
Key Findings:
DHA was an independent protective factor for MACE (HR = 0.83, 95% CI: 0.74–0.93, P = 0.002), while MPV was an independent risk factor (HR = 1.22, 95% CI: 1.00–1.49, P = 0.046).
Interpretation:
DHA is associated with coronary stenosis severity, with partial mediation by MPV.
Limitations:
The study's observational design limits causal inferences.
The sample size may not be representative of the broader population.
Conclusion:
The study provides quantitative evidence for the associations between DHA, MPV, and coronary artery stenosis severity.
