Partial Oral Versus Intravenous Antibiotic Therapy for Endocarditis With Management by a Multidisciplinary Team: A Retrospective Cohort Study - Summary - MDSpire

Partial Oral Versus Intravenous Antibiotic Therapy for Endocarditis With Management by a Multidisciplinary Team: A Retrospective Cohort Study

  • By

  • Sami El-Dalati

  • Bennett Collis

  • Takaaki Kobayashi

  • Evan Hall

  • Talal Alnabelsi

  • Chloe Cao

  • Meredith Johnson

  • John Gurley

  • Luke Strnad

  • Corey Adams

  • Victoria Weaver

  • Hassan Reda

  • Michael Sekela

  • Tessa London

  • Kara Kennedy

  • Armaghan-E Rehman Mansoor

  • David Olafsson

  • Grant Laugherty

  • Alyssa Tremblay

  • Angella Linder

  • Deborah Gill

  • Nicholas J Van Sickels

  • Alexander Pomakov

  • William Harris

  • Bobbi Jo Stoner

  • October 28, 2025

  • 0 min

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Objective:

To evaluate the outcomes of patients with infective endocarditis (IE) treated with either intravenous (IV) or partial oral antibiotics by a multidisciplinary team.

Key Findings:
  • No significant differences in 90-day relapsed infection (0.7% vs 2.2%; P = .32) or all-cause mortality (2.8% vs 6.5%; P = .17) between IV and oral therapy.
  • Oral therapy was not associated with increased 90-day mortality (OR, 1.72; P = .46).
  • Independent predictors of mortality included older age, acute heart failure, and discharge before medically advised.
Interpretation:

Partial oral therapy for IE appears to be safe and effective, with outcomes comparable to exclusive IV treatment, supporting European guidelines.

Limitations:
  • Single-center study may limit generalizability.
  • Retrospective design may introduce selection bias.
Conclusion:

In selected patients managed by a multidisciplinary team, partial oral therapy for IE is a viable alternative to IV treatment.

Original Source(s)

Partial Oral Versus Intravenous Antibiotic Therapy for Endocarditis With Management by a Multidisciplinary Team: A Retrospective Cohort Study

  • by Sami El-Dalati, Bennett Collis, Takaaki Kobayashi, Evan Hall, Talal Alnabelsi, Chloe Cao, Meredith Johnson, John Gurley, Luke Strnad, Corey Adams, Victoria Weaver, Hassan Reda, Michael Sekela, Tessa London, Kara Kennedy, Armaghan-E Rehman Mansoor, David Olafsson, Grant Laugherty, Alyssa Tremblay, Angella Linder, Deborah Gill, Nicholas J Van Sickels, Alexander Pomakov, William Harris, Bobbi Jo Stoner

  • October 28, 2025

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