To clarify the trend of precocious puberty (PP) incidence after the COVID-19 outbreak and explore potential contributing factors, including but not limited to age at presentation and body mass index (BMI) SD score (SDS).
Key Findings:
The COVID-19 pandemic was associated with increased odds of PP (odds ratio = 1.96; 95% CI, 1.56-2.47; P < .001), indicating a significant public health concern.
BMI SDS did not vary significantly between the two periods.
Age at presentation for PP was lower after the pandemic, suggesting delayed diagnosis may have contributed to increased incidence.
Interpretation:
The findings suggest a significant increase in the incidence of precocious puberty during the pandemic, potentially linked to delayed medical attention due to lockdowns and lifestyle changes such as increased sedentary behavior and caloric intake.
Limitations:
Inconsistencies in findings across studies regarding PP incidence.
Diversity of measurements and definitions of PP may affect generalizability.
Potential biases in study selection and reporting may influence results.
Conclusion:
The incidence of precocious puberty increased more rapidly during the pandemic than in the prepandemic period, highlighting the need for early diagnosis and treatment.
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