To evaluate the association between adjunctive systemic corticosteroid use and clinical outcomes in children hospitalized with orbital cellulitis, highlighting its significance in pediatric care.
Key Findings:
Corticosteroid use did not significantly reduce hospital length of stay (mean difference −0.43 days), but was associated with increased risks of surgical intervention (RR 2.08), PICU admission (RR 1.82), and 30-day readmission (RR 2.53), raising concerns for clinical practice.
Interpretation:
Adjunctive corticosteroids do not shorten hospitalization and may increase adverse outcomes in pediatric orbital cellulitis; caution is advised in clinical application.
Limitations:
Most included studies were observational, leading to potential confounding and biases that may affect the results' reliability.
Conclusion:
High-quality randomized controlled trials are needed to clarify the role of corticosteroids in the management of pediatric orbital cellulitis, particularly focusing on specific outcomes.
A retrospective database study found a low absolute incidence but higher relative hazard of ischemic optic neuropathy following semaglutide initiation.
