Seroprevalence of Dengue, Zika, and Chikungunya Viruses in Humans and Colocated Macaques in Thailand and Cambodia - Summary - MDSpire
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Prevalence of Antibodies Against Dengue, Zika, and Chikungunya Viruses in Humans and Nearby Macaques in Thailand and Cambodia

  • By

  • Nanthanida Mongkol

  • Sophana Chea

  • Somnang Man

  • Piseth Ly

  • Cheata Hou

  • Sokna Ly

  • Ratanak Sath

  • Chanthap Lon

  • Kry Hok

  • Huch Chea

  • Rithea Leang

  • Rekol Huy

  • Sophia B Lin

  • Fanny Sae Wang

  • Daraka Tongthainan

  • Wirasak Fungfuang

  • Sudarat Lijitipoom

  • Sarocha Suthisawat

  • Nathamon Kosoltanapiwat

  • Natanon Panpeth

  • Stephen S Whitehead

  • Fabiano Oliveira

  • Rebecca C Christofferson

  • Jessica E Manning

  • Kobporn Boonnak

  • Christina Yek

  • May 21, 2025

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Objective:

To assess the role of sylvatic reservoirs in arboviral circulation by examining serological evidence of exposure to DENV, ZIKV, and CHIKV among humans and macaques in endemic regions, highlighting the significance of understanding these dynamics for public health.

Key Findings:
  • Higher seropositivity rates for arboviruses were found in humans (38.5%–74.4%) compared to macaques (0%–8.0%). This disparity suggests differing exposure risks.
  • Seroprevalence varied between Thai and Cambodian cohorts, indicating regional differences in arboviral transmission.
  • Age was the only significant predictor of human seropositivity, emphasizing the need for targeted public health interventions.
Interpretation:

The low seropositivity among macaques suggests they have a limited role in sustaining urban arboviral cycles, indicating potential virus spillback from human populations, which has important implications for public health strategies.

Limitations:
  • Limited geographic scope with only four sampling sites, which may not represent broader trends.
  • Potential biases in human participant selection and macaque sampling methods could affect the reliability of findings.
Conclusion:

The study highlights the disparity in arboviral exposure between humans and macaques, suggesting a need for further research on the dynamics of arboviral transmission in urban settings to inform public health responses.

Original Source(s)

Seroprevalence of Dengue, Zika, and Chikungunya Viruses in Humans and Colocated Macaques in Thailand and Cambodia

  • by Nanthanida Mongkol, Sophana Chea, Somnang Man, Piseth Ly, Cheata Hou, Sokna Ly, Ratanak Sath, Chanthap Lon, Kry Hok, Huch Chea, Rithea Leang, Rekol Huy, Sophia B Lin, Fanny Sae Wang, Daraka Tongthainan, Wirasak Fungfuang, Sudarat Lijitipoom, Sarocha Suthisawat, Nathamon Kosoltanapiwat, Natanon Panpeth, Stephen S Whitehead, Fabiano Oliveira, Rebecca C Christofferson, Jessica E Manning, Kobporn Boonnak, Christina Yek

  • May 21, 2025

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