Allogeneic hematopoietic cell transplantation after infection with SARS-CoV-2 during the COVID-19 pandemic: a multicenter retrospective analysis - Summary - MDSpire

Allogeneic hematopoietic cell transplantation after infection with SARS-CoV-2 during the COVID-19 pandemic: a multicenter retrospective analysis

  • By

  • Osama Ahmad

  • Nicolaus Kröger

  • Eva Wagner-Drouet

  • David Nachbaur

  • Normann Steiner

  • Daniel Teschner

  • Sabrina Kraus

  • Gesine Bug

  • Salem Ajib

  • Johannes Schetelig

  • Wolfgang Andreas Bethge

  • Thomas Schroeder

  • Judith Schaffrath

  • Lutz Peter Müller

  • Mareike Verbeek

  • Edgar Jost

  • Hatice Soysal

  • Johanna Tischer

  • Georg-Nikolaus Franke

  • Stefan Klein

  • Udo Holtick

  • Knut Wendelin

  • Claudia Lengerke

  • Martin Bornhäuser

  • Jan Frederic Weller

  • Maximilian Christopeit

  • March 12, 2025

  • 0 min

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Objective:

To assess the impact of pre-transplant SARS-CoV-2 infection on outcomes of allogeneic hematopoietic cell transplantation (alloHCT).

Key Findings:
  • Cumulative incidences of relapse and NRM at 365 days were 17.31% and 8.32%, respectively.
  • Survival rates were significantly higher in patients with mild COVID-19 (90.9%) compared to moderate (66.7%) and severe/critical cases (51.1%).
  • A high Karnofsky Index (90-100) was associated with better disease-free survival and overall survival.
Interpretation:

COVID-19 severity significantly influences post-transplant outcomes, with mild cases showing better survival and lower NRM rates.

Limitations:
  • Retrospective design limits generalizability.
  • Small sample size and missing data on COVID-19 severity and duration.
  • Inconsistent treatment data across participating centers.
Conclusion:

COVID-19 severity and pre-transplant functional status are critical for alloHCT outcomes; preventive measures and tailored assessments are essential.

Original Source(s)

Allogeneic hematopoietic cell transplantation after infection with SARS-CoV-2 during the COVID-19 pandemic: a multicenter retrospective analysis

  • by Osama Ahmad, Nicolaus Kröger, Eva Wagner-Drouet, David Nachbaur, Normann Steiner, Daniel Teschner, Sabrina Kraus, Gesine Bug, Salem Ajib, Johannes Schetelig, Wolfgang Andreas Bethge, Thomas Schroeder, Judith Schaffrath, Lutz Peter Müller, Mareike Verbeek, Edgar Jost, Hatice Soysal, Johanna Tischer, Georg-Nikolaus Franke, Stefan Klein, Udo Holtick, Knut Wendelin, Claudia Lengerke, Martin Bornhäuser, Jan Frederic Weller, Maximilian Christopeit

  • March 12, 2025

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