Psychological Depression and Its Association with Oocyte Yield and Embryo Outcomes in Infertile Women Undergoing In Vitro Fertilization-Embryo Transfer - Summary - MDSpire
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Psychological Depression and Its Association with Oocyte Yield and Embryo Outcomes in Infertile Women Undergoing In Vitro Fertilization-Embryo Transfer
To investigate the association between depressive symptoms and IVF-related intermediate reproductive outcomes in infertile women.
Key Findings:
18.1% of participants met criteria for moderate or severe depressive symptoms.
Higher PHQ-9 scores were associated with a reduced number of transferable embryos (β = −2.17).
The association with retrieved oocyte number was of borderline statistical significance (β = −3.02).
RCS analyses indicated a negative dose–response relationship between depression severity and IVF outcomes.
Interpretation:
Depressive symptoms significantly impact the number of transferable embryos in infertile women undergoing IVF-ET, highlighting the importance of mental health in reproductive outcomes.
Limitations:
The study was conducted at a single center, which may limit generalizability.
The cross-sectional nature of the study does not establish causation.
Conclusion:
Mental health status, particularly depressive symptoms, plays a crucial role in intermediate outcomes of assisted reproductive treatments.
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