Deep Immunophenotyping Reveals Distinct Immune Signatures in Axial Spondyloarthritis and Psoriatic Arthritis - Summary - MDSpire

Comprehensive Immunophenotyping Identifies Unique Immune Profiles in Axial Spondyloarthritis and Psoriatic Arthritis

  • By

  • Natalie Frede

  • Nils Craig-Müller

  • Silke Kohrt

  • Marei-Theresa Bott

  • Ulrich Salzer

  • Ana Cecilia Venhoff

  • Jens Thiel

  • Julia Frede

  • Reinhard E. Voll

  • Marta Rizzi

  • Raquel Lorenzetti

  • Nils Venhoff

  • July 6, 2026

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Objective:

To compare immune cell subsets, cytokine profiles, and inflammatory mediators in axial spondyloarthritis (axSpA) and psoriatic arthritis (PsA), which are overlapping yet distinct conditions within the spondyloarthritis spectrum.

Approach:
  • Study Design: Peripheral blood mononuclear cells (PBMCs) from 179 patients (88 axSpA, 91 PsA) and 49 healthy donors were profiled using spectral flow cytometry.
  • Data Collection: The study involved 230 million acquired events and 55 million quality-controlled cells to analyze immune subsets, activation- and differentiation-associated markers, and cytokines.
Key Findings:
  • AxSpA exhibited an expansion of double-negative and γδ T cells.
  • Increased plasmablasts and CD21low B cells were observed in axSpA.
  • Higher expression of activation-associated markers was noted in axSpA compared to PsA.
Interpretation:

Distinct immunophenotypic profiles were identified between axSpA and PsA.

Conclusion:

The findings highlight the unique immune profiles of axSpA and PsA.

Sources:

Original Source(s)

Deep Immunophenotyping Reveals Distinct Immune Signatures in Axial Spondyloarthritis and Psoriatic Arthritis

  • by Natalie Frede, Nils Craig-Müller, Silke Kohrt, Marei-Theresa Bott, Ulrich Salzer, Ana Cecilia Venhoff, Jens Thiel, Julia Frede, Reinhard E. Voll, Marta Rizzi, Raquel Lorenzetti, Nils Venhoff

  • July 6, 2026

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