To investigate the independent association between admission pulse pressure (PP) and the risk of in-hospital mortality in heart failure patients, and its consistency across different left-ventricular ejection fraction (LVEF) phenotypes, ensuring clarity on what 'independent association' entails.
Key Findings:
Out of 21,768 patients, 1,541 (7.1%) experienced in-hospital mortality.
PP <30 mmHg independently predicted all-cause mortality (OR 1.31, 95% CI 1.06–1.60) and cardiac death (OR 1.80, 95% CI 1.38–2.35).
Lower PP (<50 mmHg) was associated with higher risk of in-hospital mortality across all LVEF strata.
Interpretation:
Low admission pulse pressure is a significant predictor of in-hospital mortality in heart failure patients, indicating a need for enhanced risk stratification and monitoring to improve patient outcomes.
Limitations:
Retrospective design may introduce selection bias.
Data derived from a single institution may limit generalizability.
Potential confounding factors not accounted for in the analysis.
Conclusion:
Integrating pulse pressure into early risk-stratification algorithms could improve triage and monitoring of hospitalized heart failure patients.
