Objective:

To investigate the associations among choroid plexus (CP) morphology, glymphatic-related fluid alterations, white matter hyperintensities (WMH), and cognitive performance in individuals with type 2 diabetes mellitus (T2DM).

Approach:

Key Findings:

• T2DM patients had lower SDMT scores and larger CP volume, FW fraction, PVS volume, and PWMH volume compared to controls (all P < 0.05).
• CP volume and FW fraction were independently associated with PWMH in T2DM patients.
• FW fraction and PWMH were independently linked to SDMT scores.
• Significant mediation effects were found through FW in the CP–PWMH association and through PWMH in the FW–SDMT association.

Interpretation:

Limitations:

• The study is cross-sectional, limiting causal inferences.
• Sample size may restrict the generalizability of findings.

Conclusion:

Attribution Notice

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