To systematically review the roles of the Nrf2, NF-κB, and MAPK pathways in osteoporosis and discuss the anti-osteoporotic mechanisms of Chinese herbal monomers.
Approach:
Pathway Interaction: The article discusses the interaction of Nrf2, NF-κB, and MAPK pathways in bone metabolism, oxidative stress, and inflammation.
Traditional Chinese Medicine: It highlights the potential of Traditional Chinese Medicine (TCM) in osteoporosis treatment through multi-target and multi-pathway actions.
Key Findings:
Osteoporosis is characterized by an imbalance between bone formation and resorption, influenced by oxidative stress and inflammation.
Nrf2, NF-κB, and MAPK pathways are crucial in regulating bone metabolism, and their dysregulation contributes to osteoporosis.
Chinese herbal monomers can modulate these pathways, restoring bone metabolic equilibrium and exhibiting anti-osteoporotic effects.
Interpretation:
The article provides a theoretical foundation for TCM intervention in osteoporosis, emphasizing syndrome differentiation and personalized treatment.
Limitations:
Current reviews focus on individual pathways or single herbal components, lacking a systematic overview of their interactions.
Conclusion:
The integration of TCM with modern understanding of osteoporosis mechanisms may enhance treatment strategies.
