Plasma PZP level elevation: a potential correlate of diabetic kidney disease progression
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By
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Lin Mao
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Ruili Yin
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Longyan Yang
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Dong Zhao
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May 28, 2026
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Objective:
To investigate the connection between plasma PZP concentrations and diabetic kidney disease (DKD).
Key Findings:
- PZP was identified as a differentially expressed protein in DKD patients according to the study.
- Plasma PZP levels were significantly increased in DKD patients compared to controls as reported.
- Positive correlations were found between plasma PZP concentrations and SBP, HbA1c, LDL, Cr, BUN, and UACR as per the study's findings.
- Negative correlations were observed with HDL and eGFR according to the study.
- Logistic regression indicated a significant correlation between PZP and DKD progression as per the study's results.
Interpretation:
The study reports that elevated plasma PZP levels are associated with DKD.
Limitations:
- The study is retrospective and may have inherent biases.
- The sample population was limited to a specific demographic (Chinese population).
Conclusion:
The study suggests that detecting plasma PZP concentrations may have implications for intervention in DKD.
