Technetium-99m-marked sentinel lymph node biopsy for oral squamous cell carcinoma as a safe and effective procedure for patient and staff - Summary - MDSpire
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Technetium-99m-marked sentinel lymph node biopsy for oral squamous cell carcinoma as a safe and effective procedure for patient and staff
To evaluate the feasibility of sentinel lymph node biopsy (SLNB) using [99mTc]Tc-albumin nanocolloid in patients with oral squamous cell carcinoma (OSCC), focusing on patient selection, radiation exposure, and oncologic outcomes during follow-up.
Approach:
Surgical Procedure: Surgery was performed with calculated radioactive decay to minimize exposure to the surgical team, and standard cervical incisions were used.
Key Findings:
16 patients included (11 males, 5 females; mean age 70.9 ± 11.1 years).
Occult lymph node metastases detected in 3 of 16 patients (18.8%).
Tumor upstaging (pT>cT) occurred in 1 patient (6.3%).
Sentinel lymph nodes successfully identified in all patients.
Mean radiation exposure for the surgeon was 2.3 μSv.
Mean administered technetium-99m activity was 100.9 ± 2.1 MBq.
Mean duration of surgery was 111.5 min.
Interpretation:
Limitations:
Limited sample size.
Short follow-up duration, which may affect the reliability of oncologic outcomes.
Conclusion:
Further prospective studies are required to establish the role of SLNB relative to elective neck dissection in OSCC management.
